Comments Requested on EPA Draft - Process for Establishing & Implementing Alternative Approaches to Traditional In Vivo Acute Toxicity Studies
The EPA is asking for comments on a new guidance to reduce the use of animals and increase relevant acute toxicity data on pesticides. The draft guidance, Process for Establishing & Implementing Alternative Approaches to Traditional In Vivo Acute Toxicity Studies, describes a transparent, stepwise process for evaluating and implementing alternative methods of testing for acute oral, dermal, and inhalation toxicity, along with skin and eye irritation and skin sensitization. In addition, there is a discussion of the three major phases of the process, and the implications for reporting information under section 6(a)(2) of the Federal Insecticide, Fungicide, and Rodenticide Act. Successfully putting this process into place will require an open dialogue with stakeholders, other regulatory organizations, and the scientific community.
Please submit any comments on the draft guidance by March 10, 2015 to Christopher Schlosser by email at firstname.lastname@example.org or regular mail at Christopher Schlosser, U.S.E.P.A, 1200 Pennsylvania Avenue, NW, MC 7509P, Washington, DC 20460.
This draft guidance is one step in the application of the Office of Pesticide Programs’ strategic vision for implementing the 2007 National Research Council report on Toxicity Testing in the 21st Century.