Please log in
I don't have an account.
Log in to Account

Cytokine Assay


Product Safety Assessment Using an In Vitro Test System Based on Viability of and Cytokine Released by Reconstructed Human Epidermis (RhE) Models

  • Assay used for the evaluation of the skin irritation potential of topically administered test materials
  • Frequently used to address the irritation profile of (but not limited to) surfactant-based formulations with rinse-off applications
  • The assay allows ranking of test materials with anticipated low irritation potential using pro-inflammatory cytokine analyses such as interleukin IL-1α
Cytokine Assay.

Assay Endpoints

  • Tissue viability
  • Cytokine expression

Applicability Domain

  • Ingredients of finished products formulated to have low irritation potential
  • Undiluted (leave-on intended use) or diluted (rinse-off intended use) materials

Use

  • Ranking of test materials’ irritation potential
  • Qualification of benchmark materials
  • Correlation with clinical data

Contact us to learn more and consult with a Study Director