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Reconstructed Skin Micronucleus Assay (RSMN)


Using the EpiDerm™ Reconstructed Human Epidermis Model

Evaluate the genotoxic potential of new ingredients and chemicals at exposure-relevant doses

  • RSMN determines the skin genotoxicity/mutagenicity potential of a test substance by determining the relative increase in the induction of micronuclei in test substance- treated tissues compared to negative control-treated tissues
  • Reconstructed human epidermal tissues may more accurately model the complexity of skin absorption, human epidermal metabolism, and tissue-specific responses than traditional monolayer culture systems
  • Complex test formulations may be applied in a biologically-relevant fashion directly onto the stratum corneum
  • Protocols allow for 48 and 72 hour exposures on the metabolically active tissues with no exogenous source of metabolic activation (S9)
  • RSMN is ideal as a 2nd tier genotoxicity test, and may be used to address positive in vitro mammalian genotoxicity test results

Please contact us for more information or to speak with one of our Study Directors.